Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	319	3q25.1	GPR171	G protein-coupled receptor 171	2
Mouse	7	319	3 D	Gpr171	G protein-coupled receptor 171
Rat	7	326	2q31	Gpr171	G protein-coupled receptor 171

Previous and Unofficial Names

G-protein coupled receptor H963 | platelet activating receptor homolog

Database Links
Specialist databases
GPCRdb	gp171_human (Hs)
Other databases
Alphafold	O14626 (Hs), Q8BG55 (Mm)
ChEMBL Target	CHEMBL4523860 (Hs)
Ensembl Gene	ENSG00000174946 (Hs), ENSMUSG00000050075 (Mm), ENSRNOG00000025297 (Rn)
Entrez Gene	29909 (Hs), 229323 (Mm), 688737 (Rn)
Human Protein Atlas	ENSG00000174946 (Hs)
KEGG Gene	hsa:29909 (Hs), mmu:229323 (Mm), rno:688737 (Rn)
Pharos	O14626 (Hs)
RefSeq Nucleotide	NM_013308 (Hs), NM_173398 (Mm), NM_001109510 (Rn)
RefSeq Protein	NP_013308 (Hs), NP_775574 (Mm), NP_001102980 (Rn)
UniProtKB	O14626 (Hs), Q8BG55 (Mm)
Wikipedia	GPR171 (Hs)

Agonist Comments

GPR171 has been shown to be activated by endogenous peptide BigLEN. This receptor-peptide interaction is believed to be involved in regulating feeding and metabolism responses [1].

Immuno Process Associations

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0045638 negative regulation of myeloid cell differentiation IEA

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0045638 negative regulation of myeloid cell differentiation IEA

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  I283V Global MAF (%):  5 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 2|3|13|1 Minor allele count:  C=0.047/103 SNP accession:  rs3732756 Validation:  1000 Genomes, HapMap, Frequency

General Comments
GPR171 is excluded as a candidate gene of Usher syndrome Type 3 [3].