Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	462	17q25.1	GPR142	G protein-coupled receptor 142	1-2
Mouse	7	365	11 E2	Gpr142	G protein-coupled receptor 142	1-2
Rat	7	340	10q32.1	Gpr142	G protein-coupled receptor 142

Previous and Unofficial Names

KIF19 | AXOR103 | G-protein coupled receptor PGR2

Database Links
Specialist databases
GPCRdb	gp142_human (Hs), gp142_mouse (Mm)
Other databases
Alphafold	Q7Z601 (Hs), Q7TQN9 (Mm), F1LWD8 (Rn)
ChEMBL Target	CHEMBL2069161 (Hs), CHEMBL2069162 (Mm), CHEMBL3632456 (Rn)
Ensembl Gene	ENSG00000257008 (Hs), ENSMUSG00000034677 (Mm), ENSRNOG00000024446 (Rn)
Entrez Gene	350383 (Hs), 217302 (Mm), 501735 (Rn)
Human Protein Atlas	ENSG00000257008 (Hs)
KEGG Gene	hsa:350383 (Hs), mmu:217302 (Mm), rno:501735 (Rn)
OMIM	609046 (Hs)
Pharos	Q7Z601 (Hs)
RefSeq Nucleotide	NM_181790 (Hs), NM_181749 (Mm)
RefSeq Protein	NP_861455 (Hs), NP_861414 (Mm)
UniProtKB	Q7Z601 (Hs), Q7TQN9 (Mm), F1LWD8 (Rn)
Wikipedia	GPR142 (Hs)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 33 [Toda et al., 2013] Hs Agonist 7.7 pEC50 3 ⤷ pEC50 7.7 (EC50 2.2x10-8 M) [3]
Agonist Comments
The high identity of 50% between GPR142 and GPR139 is suggestive of shared ligands [2].

Tissue Distribution
Spleen, liver, kidney, testis, brain Species:  Mouse Technique:  Multi-tissue cDNA panel (PCR) References:  2
Brain (intense labeling of hippocampus, dentate gyrus, cerebral cortex, medial thalamic nuclei, anterior hypothalamic nuclei), thymus, liver, cartilage Species:  Mouse Technique:  In situ hybridization References:  2
Tissue Distribution Comments
Embryonic expression of GPR142 suggests the receptor may play a role in brain, bone and blood formation [2].

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  R86H Global MAF (%):  1 Subpopulation MAF (%):  ASN: 3 Minor allele count:  A=0.007/16 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs76896732 Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  H132D Global MAF (%):  3 Subpopulation MAF (%):  AFR|AMR: 12|3 Minor allele count:  C=0.032/70 SNP accession:  rs2382647 Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  R124Q Global MAF (%):  1 Subpopulation MAF (%):  AFR: 3 Minor allele count:  A=0.006/14 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs73997706 Validation:  1000 Genomes, Frequency