Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	508	Xq26.3	GPR101	G protein-coupled receptor 101
Mouse	7	511	X A6	Gpr101	G protein-coupled receptor 101
Rat	7	508	Xq36	Gpr101	G protein-coupled receptor 101

Previous and Unofficial Names

GPCR6

Database Links
Specialist databases
GPCRdb	gp101_human (Hs), gp101_mouse (Mm), d4abk4_rat (Rn)
Other databases
Alphafold	Q96P66 (Hs), Q80T62 (Mm), D4ABK4 (Rn)
ChEMBL Target	CHEMBL4523906 (Hs)
Ensembl Gene	ENSG00000165370 (Hs), ENSMUSG00000036357 (Mm), ENSRNOG00000027658 (Rn)
Entrez Gene	83550 (Hs), 245424 (Mm), 317608 (Rn)
Human Protein Atlas	ENSG00000165370 (Hs)
KEGG Gene	hsa:83550 (Hs), mmu:245424 (Mm), rno:317608 (Rn)
OMIM	300393 (Hs)
Pharos	Q96P66 (Hs)
RefSeq Nucleotide	NM_054021 (Hs), NM_001108258 (Mm), NM_001033360 (Mm)
RefSeq Protein	NP_473362 (Hs), NP_001028532 (Mm), NP_001101728 (Rn)
UniProtKB	Q96P66 (Hs), Q80T62 (Mm), D4ABK4 (Rn)
Wikipedia	GPR101 (Hs)

Primary Transduction Mechanisms
Transducer	Effector/Response
Gs family	Adenylyl cyclase stimulation
Comments:  G-protein coupling predicted by knowledge-restricted hidden Markov model-based algorithm, and confirmed by mammalian and yeast cell transfection models [1].
References:  1

Tissue Distribution
Caudate putamen, hypothalamus Species:  Human Technique:  Northern blot References:  1,3
Brain, spinal cord Species:  Mouse Technique:  Northern blot References:  1
Tissue Distribution Comments
Murine mRNA detected in all brain regions, with strongest signals in the hypothalamus. Prominent expression highly restricted to dopaminergic, serotonergic and noradrenergic nuclei [1].

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Clinically-Relevant Mutations and Pathophysiology Comments

Human missense SNP P432L (rs148692008; dbSNP) has been identified as associated with melanoma by whole exome sequencing, but remains untested [4]. Methylation of the GPR101 gene promoter in stage IV colorectal cancer is correlated with longer time to progression. Tumour specific hypermethylation observed [2].

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  V124L Global MAF (%):  30 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 2|24|34|49 Minor allele count:  A=0.303/503 SNP accession:  VAR_049398, rs1190736 Validation:  1000 Genomes, HapMap
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  V238I Global MAF (%):  1 Subpopulation MAF (%):  AFR|AMR: 4|1 Minor allele count:  T=0.011/18 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs139111924 Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  L376P Global MAF (%):  16 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 26|13|11|14 Minor allele count:  G=0.159/263 SNP accession:  VAR_049399, rs5931046 Validation:  1000 Genomes, HapMap
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  T293I Global MAF (%):  5 Subpopulation MAF (%):  AFR|AMR|ASN: 19|1|1 Minor allele count:  A=0.050/83 SNP accession:  rs73566014 Validation:  1000 Genomes, Frequency