Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	731	3q25.2	GPR149	G protein-coupled receptor 149
Mouse	7	732	3 E1	Gpr149	G protein-coupled receptor 149
Rat	7	730	2q31	Gpr149	G protein-coupled receptor 149

Previous and Unofficial Names

IEDA | G-protein coupled receptor PGR10 | induced early in differentiating astrocytes gene protein

Database Links
Alphafold	Q86SP6 (Hs), Q3UVY1 (Mm), Q924Y8 (Rn)
ChEMBL Target	CHEMBL4523883 (Hs)
Ensembl Gene	ENSG00000174948 (Hs), ENSMUSG00000043441 (Mm), ENSRNOG00000014793 (Rn)
Entrez Gene	344758 (Hs), 229357 (Mm), 192251 (Rn)
Human Protein Atlas	ENSG00000174948 (Hs)
KEGG Gene	hsa:344758 (Hs), mmu:229357 (Mm), rno:192251 (Rn)
Pharos	Q86SP6 (Hs)
RefSeq Nucleotide	NM_001038705 (Hs), NM_177346 (Mm), NM_138891 (Rn)
RefSeq Protein	NP_001033794 (Hs), NP_796320 (Mm), NP_620246 (Rn)
UniProtKB	Q86SP6 (Hs), Q3UVY1 (Mm), Q924Y8 (Rn)
Wikipedia	GPR149 (Hs)

Tissue Distribution
Ovary, brain, digestive tract Species:  Mouse Technique:  RT-PCR References:  1

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Physiological Consequences of Altering Gene Expression
Increased fertility and enhanced ovulation, with increased levels of FSH receptor and cyclin D2 mRNA levels, in receptor knockout mice Species:  Mouse Tissue:  Oocytes, granulosa cells Technique:  Gene knockout References:  1
GPR149 deficiency reduced oligodendrocyte progenitor cell maturation Species:  Mouse Tissue:  Technique:  References:  2
Global knockout reduced weight gain in mice fed a high fat diet Species:  Mouse Tissue:  Whole animal Technique:  CRISPR-Cas9 References:  3

Phenotypes, Alleles and Disease Models

Mouse data from MGI

Show »« Hide Allele Composition & genetic background Accession Phenotype Id Phenotype Reference Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:2443628  MP:0001927 abnormal estrous cycle PMID: 19887567  Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:2443628  MP:0002161 abnormal fertility/fecundity PMID: 19887567  Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:2443628  MP:0005410 abnormal fertilization PMID: 19887567  Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:2443628  MP:0001130 abnormal ovarian folliculogenesis PMID: 19887567  Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:2443628  MP:0001928 abnormal ovulation PMID: 19887567  Gpr149+|Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149+ involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:2443628  MP:0001928 abnormal ovulation PMID: 19887567  Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:2443628  MP:0001934 increased litter size PMID: 19887567  Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:2443628  MP:0008870 increased mature ovarian follicle number PMID: 19887567  Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:2443628  MP:0009017 prolonged estrus PMID: 19887567