Top ▲
GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
Gene and Protein Information ![]()  | 
                                    ||||||
| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference | 
| Human | 7 | 305 | 7p14.1 | GPR141 | G protein-coupled receptor 141 | |
| Mouse | 7 | 305 | 13 A2 | Gpr141 | G protein-coupled receptor 141 | |
| Rat | 5 | 247 | 17q11 | Gpr141 | G protein-coupled receptor 141 | |
Previous and Unofficial Names ![]()  | 
                                
| axor115 | G-protein coupled receptor PGR13 | 
Database Links ![]()  | 
                            |
| Alphafold | Q7Z602 (Hs), Q7TQP0 (Mm), Q7TQN5 (Rn) | 
| ChEMBL Target | CHEMBL4523879 (Hs) | 
| Ensembl Gene | ENSG00000187037 (Hs), ENSMUSG00000053101 (Mm), ENSRNOG00000066332 (Rn), ENSRNOG00000059698 (Rn) | 
| Entrez Gene | 353345 (Hs), 353346 (Mm), 291179 (Rn) | 
| Human Protein Atlas | ENSG00000187037 (Hs) | 
| KEGG Gene | hsa:353345 (Hs), mmu:353346 (Mm), rno:291179 (Rn) | 
| OMIM | 609045 (Hs) | 
| Pharos | Q7Z602 (Hs) | 
| RefSeq Nucleotide | NM_181791 (Hs), NM_181754 (Mm), NM_181767 (Rn) | 
| RefSeq Protein | NP_861456 (Hs), NP_861419 (Mm), NP_861432 (Rn) | 
| UniProtKB | Q7Z602 (Hs), Q7TQP0 (Mm), Q7TQN5 (Rn) | 
| Wikipedia | GPR141 (Hs) | 
| Immunopharmacology Comments | 
| May function as an inflammation suppressor in myeloid cells [2]. | 
Tissue Distribution  
                                             | 
                                    ||||||||
                                            
  | 
                                    
Expression Datasets ![]()  | 
                                |
                                        
  | 
                                
1. Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2003) Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett, 554 (3): 381-8. [PMID:14623098]
2. Sawabe A, Okazaki S, Nakamura A, Goitsuka R, Kaifu T. (2024) The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor. J Leukoc Biol, 115 (5): 935-945. [PMID:38226682]