Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	494	14q23.1	GPR135	G protein-coupled receptor 135
Mouse	7	457	12 C3	Gpr135	G protein-coupled receptor 135
Rat	7	457	6q24	Gpr135	G protein-coupled receptor 135

Previous and Unofficial Names

HUMNPIIY20 | PAFR

Database Links
Specialist databases
GPCRdb	gp135_human (Hs), gp135_mouse (Mm), gp135_rat (Rn)
Other databases
Alphafold	Q8IZ08 (Hs), Q7TQP2 (Mm), Q7TQN7 (Rn)
ChEMBL Target	CHEMBL3309102 (Hs)
Ensembl Gene	ENSG00000181619 (Hs), ENSMUSG00000043398 (Mm), ENSRNOG00000004499 (Rn)
Entrez Gene	64582 (Hs), 238252 (Mm), 314213 (Rn)
Human Protein Atlas	ENSG00000181619 (Hs)
KEGG Gene	hsa:64582 (Hs), mmu:238252 (Mm), rno:314213 (Rn)
OMIM	607970 (Hs)
Pharos	Q8IZ08 (Hs)
RefSeq Nucleotide	NM_022571 (Hs), NM_181752 (Mm), NM_181771 (Rn)
RefSeq Protein	NP_072093 (Hs), NP_861417 (Mm), NP_861436 (Rn)
UniProtKB	Q8IZ08 (Hs), Q7TQP2 (Mm), Q7TQN7 (Rn)
Wikipedia	GPR135 (Hs)

Tissue Distribution
Pituitary Species:  Human Technique:  Northern Blot References:  2
Neuron, stomach, eye, cervix, testis Species:  Human Technique:  Expressed sequence tag References:  1

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  S191N Global MAF (%):  1 Subpopulation MAF (%):  ASN: 3 Minor allele count:  T=0.007/16 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs76859844 Validation:  1000 Genomes
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  V481A Global MAF (%):  2 Subpopulation MAF (%):  AFR: 9 Minor allele count:  G=0.020/44 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs1752427 Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  Q5P Global MAF (%):  47 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 53|24|45|55 Minor allele count:  G=0.468/1023 SNP accession:  rs1752428 Validation:  1000 Genomes