<i>GPR161</i> | Class A Orphans with no pharmacology | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

GPR161

Target id: 141

Nomenclature: GPR161

Family: Class A Orphans with no pharmacology

Gene and Protein Information
Previous and Unofficial Names
Database Links
Other Binding Ligands
Tissue Distribution
Expression Datasets
Physiological Consequences of Altering Gene Expression
Phenotypes, Alleles and Disease Models
Clinically-Relevant Mutations and Pathophysiology
Biologically Significant Variants
References
How to cite this page

Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	529	1q24.2	GPR161	G protein-coupled receptor 161
Mouse	7	545	1 72.64 cM	Gpr161	G protein-coupled receptor 161
Rat	7	528	13q23	Gpr161	G protein-coupled receptor 161

Previous and Unofficial Names
G-protein coupled receptor RE2

Previous and Unofficial Names

G-protein coupled receptor RE2

Database Links
Specialist databases
GPCRdb	gp161_human (Hs), gp161_mouse (Mm)
Other databases
Alphafold	Q8N6U8 (Hs), B2RPY5 (Mm), F1M5Q2 (Rn)
ChEMBL Target	CHEMBL4523894 (Hs)
Ensembl Gene	ENSG00000143147 (Hs), ENSMUSG00000040836 (Mm), ENSRNOG00000003073 (Rn)
Entrez Gene	23432 (Hs), 240888 (Mm), 289180 (Rn)
Human Protein Atlas	ENSG00000143147 (Hs)
KEGG Gene	hsa:23432 (Hs), mmu:240888 (Mm), rno:289180 (Rn)
OMIM	612250 (Hs)
Pharos	Q8N6U8 (Hs)
RefSeq Nucleotide	NM_153832 (Hs), NM_001081126 (Mm)
RefSeq Protein	NP_722561 (Hs), NP_001074595 (Mm)
UniProtKB	Q8N6U8 (Hs), B2RPY5 (Mm), F1M5Q2 (Rn)
Wikipedia	GPR161 (Hs)

Other Binding Ligands

Key to terms and symbols

Click column headers to sort

Ligand											Sp.	Action	Value	Parameter	Reference
CART(55-102) {Sp: Human}											Rn	Binding	-	-	3
⤷	[3] Description: Binding of rat peptide to Gpr162 in rat INS-1 832/13 pancreatic islet cells.

Tissue Distribution

Mouse embryo. Expressed from E8.5 to E11.5. At E8.0-E9.5, expression was restricted to the lateral neural folds of the neural plate. Gpr161 is expressed at all examined stages of lens development: lens pit (E10.5), lens vesicle (E11.5), primary lens fiber cells (E12.5), and differentiating secondary lens fiber cells (E14.5). At E12.5 and E14.5, Gpr161 transcripts are restricted to differentiating lens fiber cells and are absent from the proliferating anterior lens epithelium. Gpr161 is also expressed in a number of other structures from E9.5 to E12.5, including the ventricular zone of the developing CNS (E9.5-E11.5), the fore and hindlimbs (E12.5), and the retina (E10.5-E14.5).

Species:	Mouse
Technique:	RT-PCR, In situ hybridization
References:	4

Expression Datasets

Show »« Hide

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!

Physiological Consequences of Altering Gene Expression Comments
GPR161 is required for right-left patterning in zebrafish development via modulation of Ca²⁺ in cells surrounding Kupffer's vesicles [2].

Phenotypes, Alleles and Disease Models

Mouse data from MGI

Show »« Hide

Allele	Composition & genetic background	Accession	Phenotype Id	Phenotype	Reference
Gpr161^vl	Gpr161^vl/Gpr161^vl C3H/HeSn-Gpr161/J	MGI:2685054	MP:0001303	abnormal lens morphology
Gpr161^vl	Gpr161^vl/Gpr161^vl C3H/HeSn-Gpr161/J	MGI:2685054	MP:0004837	abnormal neural fold formation	PMID: 1731393
Gpr161^vl	Gpr161^vl/Gpr161^vl C3H/HeSn-Gpr161/J	MGI:2685054	MP:0000373	belly spot
Gpr161^vl	Gpr161^vl/Gpr161^vl C3H/HeSn-Gpr161/J	MGI:2685054	MP:0001304	cataracts
Gpr161^vl\|Modvl3^MOLF/EiJ	Gpr161^vl/Gpr161^vl,Modvl3^MOLF/EiJ/Modvl3^MOLF/EiJ involves: C3H/HeSnJ * MOLF/EiJ	MGI:2685054 MGI:3784974	MP:0001304	cataracts	PMID: 18250320
Gpr161^vl\|Modvl3^C3H/HeSnJ\|Modvl3^MOLF/EiJ	Gpr161^vl/Gpr161^vl,Modvl3^C3H/HeSnJ/Modvl3^MOLF/EiJ involves: C3H/HeSnJ * MOLF/EiJ	MGI:2685054 MGI:3784974	MP:0001304	cataracts	PMID: 18250320
Gpr161^vl	Gpr161^vl/Gpr161^vl involves: C3H/HeSnJ * C57BL/6J	MGI:2685054	MP:0000755	hindlimb paralysis	PMID: 18250320
Gpr161^vl	Gpr161^vl/Gpr161^vl involves: C3H/HeSnJ * CAST/Ei	MGI:2685054	MP:0000755	hindlimb paralysis	PMID: 18250320
Gpr161^vl	Gpr161^vl/Gpr161^vl C3H/HeSn-Gpr161/J	MGI:2685054	MP:0003054	spina bifida
Gpr161^vl	Gpr161^vl/Gpr161^vl involves: C3H/HeSnJ * C57BL/6J	MGI:2685054	MP:0003054	spina bifida	PMID: 18250320
Gpr161^vl	Gpr161^vl/Gpr161^vl involves: C3H/HeSnJ * CAST/Ei	MGI:2685054	MP:0003054	spina bifida	PMID: 18250320
Gpr161^vl\|Modvl1^C3H/HeSnJ	Gpr161^vl/Gpr161^vl,Modvl1^C3H/HeSnJ/Modvl1^C3H/HeSnJ involves: C3H/HeSnJ * C57BL/6J	MGI:2685054 MGI:3784970	MP:0003054	spina bifida	PMID: 18250320
Gpr161^vl\|Modvl1^C3H/HeSnJ\|Modvl1^C57BL/6J	Gpr161^vl/Gpr161^vl,Modvl1^C3H/HeSnJ/Modvl1^C57BL/6J involves: C3H/HeSnJ * C57BL/6J	MGI:2685054 MGI:3784970	MP:0003054	spina bifida	PMID: 18250320
Gpr161^vl\|Modvl2^C3H/HeSnJ	Gpr161^vl/Gpr161^vl,Modvl2^C3H/HeSnJ/Modvl2^C3H/HeSnJ involves: C3H/HeSnJ * CAST/EiJ	MGI:2685054 MGI:3784972	MP:0003054	spina bifida	PMID: 18250320
Gpr161^vl\|Modvl2^C3H/HeSnJ\|Modvl2^CAST/EiJ	Gpr161^vl/Gpr161^vl,Modvl2^C3H/HeSnJ/Modvl2^CAST/EiJ involves: C3H/HeSnJ * CAST/EiJ	MGI:2685054 MGI:3784972	MP:0003054	spina bifida	PMID: 18250320

Clinically-Relevant Mutations and Pathophysiology

Disease:

Irritable bowel syndrome

Disease Ontology:

DOID:9778

Comments:

Mucosal expression of GPR161 expression was decreased after infection with Campylobacter jejuni in postinfectious irritable bowel syndrome.

References:

Clinically-Relevant Mutations and Pathophysiology Comments

A C-terminal truncation (deletion) mutation in Gpr61 causes congenital cataracts and neural tube defects in the vacuolated lens (vl) mouse mutant. Foxe3 is a genetic modifier that interacts with GPR161 to regulate lens development [4]. The mutated receptor is associated with cataract, spina bifidia and white belly spot phenotypes in mice [1].

Biologically Significant Variant Comments
The vacuolated lens C-terminal GPR161 truncation mutation affects receptor mediated endocytosis [4].

Biologically Significant Variant Comments

The vacuolated lens C-terminal GPR161 truncation mutation affects receptor mediated endocytosis [4].

References

Show »« Hide

1. Korstanje R, Desai J, Lazar G, King B, Rollins J, Spurr M, Joseph J, Kadambi S, Li Y, Cherry A, Matteson PG, Paigen B, Millonig JH. (2008) Quantitative trait loci affecting phenotypic variation in the vacuolated lens mouse mutant, a multigenic mouse model of neural tube defects. Physiol Genomics, 35 (3): 296-304. [PMID:18796533]

2. Leung T, Humbert JE, Stauffer AM, Giger KE, Chen H, Tsai HJ, Wang C, Mirshahi T, Robishaw JD. (2008) The orphan G protein-coupled receptor 161 is required for left-right patterning. Dev Biol, 323 (1): 31-40. [PMID:18755178]

3. Lindqvist A, Abels M, Shcherbina L, Ngara M, Kryvokhyzha D, Chriett S, Riva M, Fajul A, Barghouth M, Luan C et al.. (2023) GPR162 is a beta cell CART receptor. iScience, 26 (12): 108416. [PMID:38077141]

4. Matteson PG, Desai J, Korstanje R, Lazar G, Borsuk TE, Rollins J, Kadambi S, Joseph J, Rahman T, Wink J, Benayed R, Paigen B, Millonig JH. (2008) The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development. Proc Natl Acad Sci USA, 105 (6): 2088-93. [PMID:18250320]

5. Swan C, Duroudier NP, Campbell E, Zaitoun A, Hastings M, Dukes GE, Cox J, Kelly FM, Wilde J, Lennon MG et al.. (2013) Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα. Gut, 62 (7): 985-94. [PMID:22684480]

How to cite this page

Select citation format:

GPR161

Contents:

References

How to cite this page