- Guide to PHARMACOLOGY
Synonyms: Acticort® | Efmody® | Plenadren®
cortisol is an approved drug (FDA (1953, prior history unavailable), EMA (2011))
Compound class: Metabolite or derivative
Comment: Cortisol is an endogenous adrenal glucocorticoid with immunosuppressant action. Approved as hydrocortisone. Hydrocortisone is a glucocorticoid receptor agonist.
Marketed formulations may contain hydrocortisone acetate (PubChem CID 5744).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: cortisol
|Compound class||Metabolite or derivative|
|Approved drug?||Yes (FDA (1953, prior history unavailable), EMA (2011))|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (22nd List, 2021). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|International Nonproprietary Names|
|Acticort® | Efmody® | Plenadren®|
|CAS Registry No.||50-23-7 (source: Scifinder)|
|GtoPdb PubChem SID||53801089|
|RCSB PDB Ligand||HCY|
|Search Google for chemical match using the InChIKey||JYGXADMDTFJGBT-VWUMJDOOSA-N|
|Search Google for chemicals with the same backbone||JYGXADMDTFJGBT|
|Search PubMed clinical trials||hydrocortisone|
|Search PubMed titles||hydrocortisone|
|Search PubMed titles/abstracts||hydrocortisone|
|SynPHARM||6573 (in complex with Glucocorticoid receptor)|
|UniChem Compound Search for chemical match using the InChIKey||JYGXADMDTFJGBT-VWUMJDOOSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||JYGXADMDTFJGBT-VWUMJDOOSA-N|
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Hydrocortisone (links to external site)
Cat. No. 4093