Synonyms: ARA 290 | ARA-290 | PH-BSP | PHBSP
Compound class:
Peptide or derivative
Comment: Cibinetide (ARA 290) is an engineered peptide that mimics the 3 dimensional structure of the helix B surface domain of erythropoietin (EPO). It is designed to bind selectively to the non-hematopoietic EPO receptor (sometimes referred to as the innate repair receptor or IRR), that is believed to be a heterodimer of EPOR and the cytokine family beta common receptor (βCR, CD131) [1-2]. Non-hematopoietic EPO ligands have potential tissue protective and anti-inflammatory actions [4-6,8-10]. The IRR is suggested to be a point of integration between the immune system and pain signalling (via nociception) [11].
Cibinetide is SEQ ID NO. 282 (and peptide ID) as claimed in patent WO2009094172 [3]. |
Peptide Sequence | |
XEQLERALNSS | |
H-Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH |
HELM Notation | |
PEPTIDE1{[Glp].E.Q.L.E.R.A.L.N.S.S}$$$$ |
Chemical Modification | |
X in the one letter sequence is pyroglutamate (pGlu). |
Download 2D Structure | |
Canonical SMILES | Download |
Isomeric SMILES | Download |
InChI standard identifier | Download |
InChI standard key | Download |
Molecular structure representations generated using Open Babel