TC14012   Click here for help

GtoPdb Ligand ID: 2902

Synonyms: TC 14012 | TC-14012
Immunopharmacology Ligand
Compound class: Peptide
Comment: TC14012 is a CXCR4 antagonist; also CXCR7 agonist
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Peptide Sequence Click here for help
RRACYXKXPYRXCR
Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2
Chemical Modification
Disulphide bond between cysteine residues at positions 4 and 14; amidation of C-terminal arginine residue; residue 3 is 3-napthylalanine (Nal); residues 6 and 8 are citruliline (Cit) and D-citruliline (D-Cit) (N5-aminocarbonylornithine) respectively.