C12-iE-DAP

Home
Ligands
C12-iE-DAP

GtoPdb Ligand ID: 9508

Compound class: Peptide or derivative

Comment: C12-iE-DAP is an acylated derivative of the dipeptide γ-iE-DAP. It is present in the peptidoglycan (PGN) of Gram-negative bacilli and select Gram-positive bacteria. It is a NOD1 ligand.

Summary
Biological activity
References

References
1. Lee J, Tattoli I, Wojtal KA, Vavricka SR, Philpott DJ, Girardin SE. (2009) pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem, 284 (35): 23818-29. [PMID:19570976]

References

1. Lee J, Tattoli I, Wojtal KA, Vavricka SR, Philpott DJ, Girardin SE. (2009)
pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling.
J Biol Chem, 284 (35): 23818-29. [PMID:19570976]