Compound class:
Metabolite
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Haber MT, Fukui T, Lebowitz MS, Lowenstein JM. (1991)
Activation of phosphoinositide-specific phospholipase C delta from rat liver by polyamines and basic proteins. Arch Biochem Biophys, 288 (1): 243-9. [PMID:1654825] |
2. Hiasa M, Miyaji T, Haruna Y, Takeuchi T, Harada Y, Moriyama S, Yamamoto A, Omote H, Moriyama Y. (2014)
Identification of a mammalian vesicular polyamine transporter. Sci Rep, 4: 6836. [PMID:25355561] |
3. Homma Y, Emori Y. (1995)
A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities. EMBO J, 14 (2): 286-91. [PMID:7835339] |
4. Ishihara K, Hiraoka M, Ochi R. (1996)
The tetravalent organic cation spermine causes the gating of the IRK1 channel expressed in murine fibroblast cells. J Physiol (Lond.), 491 ( Pt 2): 367-81. [PMID:8866861] |
5. Kozak JA, Kerschbaum HH, Cahalan MD. (2002)
Distinct properties of CRAC and MIC channels in RBL cells. J Gen Physiol, 120 (2): 221-35. [PMID:12149283] |
6. Lopatin AN, Makhina EN, Nichols CG. (1994)
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature, 372 (6504): 366-9. [PMID:7969496] |
7. Murthy SN, Lomasney JW, Mak EC, Lorand L. (1999)
Interactions of G(h)/transglutaminase with phospholipase Cdelta1 and with GTP. Proc Natl Acad Sci USA, 96 (21): 11815-9. [PMID:10518533] |
8. Nilius B, Prenen J, Voets T, Droogmans G. (2004)
Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b. Pflugers Arch, 448 (1): 70-5. [PMID:14758478] |
9. Park D, Jhon DY, Lee CW, Lee KH, Rhee SG. (1993)
Activation of phospholipase C isozymes by G protein beta gamma subunits. J Biol Chem, 268 (7): 4573-6. [PMID:8383116] |
10. Quinn SJ, Ye CP, Diaz R, Kifor O, Bai M, Vassilev P, Brown E. (1997)
The Ca2+-sensing receptor: a target for polyamines. Am J Physiol, 273 (4): C1315-23. [PMID:9357776] |
11. Ullrich ND, Voets T, Prenen J, Vennekens R, Talavera K, Droogmans G, Nilius B. (2005)
Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium, 37 (3): 267-78. [PMID:15670874] |
12. Yang J, Jan YN, Jan LY. (1995)
Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel. Neuron, 14 (5): 1047-54. [PMID:7748552] |