Zn2+   Click here for help

GtoPdb Ligand ID: 566

Synonyms: zinc | zinc ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Andersson DA, Gentry C, Moss S, Bevan S. (2009)
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
Proc Natl Acad Sci USA, 106 (20): 8374-9. [PMID:19416844]
2. Bloomenthal AB, Goldwater E, Pritchett DB, Harrison NL. (1994)
Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.
Mol Pharmacol, 46 (6): 1156-9. [PMID:7808436]
3. Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG. (2004)
Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels.
J Neurosci, 24 (40): 8678-89. [PMID:15470133]
4. Coulter KL, Périer F, Radeke CM, Vandenberg CA. (1995)
Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR.
Neuron, 15 (5): 1157-68. [PMID:7576658]
5. Davies PA, Wang W, Hales TG, Kirkness EF. (2003)
A novel class of ligand-gated ion channel is activated by Zn2+.
J Biol Chem, 278 (2): 712-7. [PMID:12381728]
6. Gill CH, Peters JA, Lambert JJ. (1995)
An electrophysiological investigation of the properties of a murine recombinant 5-HT3 receptor stably expressed in HEK 293 cells.
Br J Pharmacol, 114 (6): 1211-21. [PMID:7620711]
7. Goytain A, Quamme GA. (2005)
Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters.
Physiol Genomics, 21 (3): 337-42. [PMID:15713785]
8. Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, Storjohann L, Stidsen CE, Jones R, Beck-Sickinger AG, Schwartz TW. (2007)
GPR39 signaling is stimulated by zinc ions but not by obestatin.
Endocrinology, 148: 13-20. [PMID:16959833]
9. Hu H, Bandell M, Petrus MJ, Zhu MX, Patapoutian A. (2009)
Zinc activates damage-sensing TRPA1 ion channels.
Nat Chem Biol, 5 (3): 183-90. [PMID:19202543]
10. Hubbard PC, Lummis SC. (2000)
Zn(2+) enhancement of the recombinant 5-HT(3) receptor is modulated by divalent cations.
Eur J Pharmacol, 394 (2-3): 189-97. [PMID:10771284]
11. Jiang Q, Papasian CJ, Wang JQ, Xiong ZG, Chu XP. (2010)
Inhibitory regulation of acid-sensing ion channel 3 by zinc.
Neuroscience, 169 (2): 574-83. [PMID:20580786]
12. Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S. (2006)
Pharmacological properties of GABAA receptors containing gamma1 subunits.
Mol Pharmacol, 69 (2): 640-9. [PMID:16272224]
13. Krishek BJ, Moss SJ, Smart TG. (1998)
Interaction of H+ and Zn2+ on recombinant and native rat neuronal GABAA receptors.
J Physiol (Lond.), 507 ( Pt 3): 639-52. [PMID:9508826]
14. Laube B, Kuhse J, Rundström N, Kirsch J, Schmieden V, Betz H. (1995)
Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.
J Physiol (Lond.), 483 ( Pt 3): 613-9. [PMID:7776247]
15. Lynch JW, Jacques P, Pierce KD, Schofield PR. (1998)
Zinc potentiation of the glycine receptor chloride channel is mediated by allosteric pathways.
J Neurochem, 71 (5): 2159-68. [PMID:9798943]
16. Miller PS, Beato M, Harvey RJ, Smart TG. (2005)
Molecular determinants of glycine receptor alphabeta subunit sensitivities to Zn2+-mediated inhibition.
J Physiol (Lond.), 566 (Pt 3): 657-70. [PMID:15905212]
17. Miller PS, Da Silva HM, Smart TG. (2005)
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.
J Biol Chem, 280 (45): 37877-84. [PMID:16144831]
18. Müller A, Kleinau G, Piechowski CL, Müller TD, Finan B, Pratzka J, Grüters A, Krude H, Tschöp M, Biebermann H. (2013)
G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.
PLoS ONE, 8 (1): e53347. [PMID:23335960]
19. Osteen JD, Mindell JA. (2008)
Insights into the ClC-4 transport mechanism from studies of Zn2+ inhibition.
Biophys J, 95 (10): 4668-75. [PMID:18658230]
20. Swaminath G, Lee TW, Kobilka B. (2003)
Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor.
J Biol Chem, 278 (1): 352-6. [PMID:12409304]
21. Swaminath G, Steenhuis J, Kobilka B, Lee TW. (2002)
Allosteric modulation of beta2-adrenergic receptor by Zn(2+).
Mol Pharmacol, 61 (1): 65-72. [PMID:11752207]
22. Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA. (2016)
Copper and protons directly activate the zinc-activated channel.
Biochem Pharmacol, 103: 109-17. [PMID:26872532]
23. Wiemer AJ, Tong H, Swanson KM, Hohl RJ. (2007)
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.
Biochem Biophys Res Commun, 353 (4): 921-5. [PMID:17208200]
24. Zhang X, Bursulaya B, Lee CC, Chen B, Pivaroff K, Jegla T. (2009)
Divalent cations slow activation of EAG family K+ channels through direct binding to S4.
Biophys J, 97 (1): 110-20. [PMID:19580749]