cisplatin   Click here for help

GtoPdb Ligand ID: 5343

Synonyms: Platinol®
Approved drug
cisplatin is an approved drug (FDA (1978))
Compound class: Inorganic
Comment: Cisplatin is a platinum-based chemotherapy drug in the same class as carboplatin and oxaliplatin. Its main action is as an alkylating agent (see Clinical Data tab for further details).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Blair BG, Larson CA, Safaei R, Howell SB. (2009)
Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin.
Clin Cancer Res, 15 (13): 4312-21. [PMID:19509135]
2. Ishida S, Lee J, Thiele DJ, Herskowitz I. (2002)
Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals.
Proc Natl Acad Sci USA, 99 (22): 14298-302. [PMID:12370430]
3. Koepsell H. (2013)
The SLC22 family with transporters of organic cations, anions and zwitterions.
Mol Aspects Med, 34 (2-3): 413-35. [PMID:23506881]