rifamycin SV

Ligand id: 4570

Name: rifamycin SV

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 6
Rotatable bonds 3
Topological polar surface area 201.31
Molecular weight 697.31
XLogP 3.97
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. DuPont HL, Petersen A, Zhao J, Mundt A, Jiang ZD, Miller S, Flores J, Shringarpure R, Moro L, Bagin RG et al.. (2014)
Targeting of rifamycin SV to the colon for treatment of travelers' diarrhea: a randomized, double-blind, placebo-controlled phase 3 study.
J Travel Med, 21 (6): 369-76. [PMID:25345982]
2. Lin SW, Lin CJ, Yang JC. (2017)
Rifamycin SV MMX for the treatment of traveler's diarrhea.
Expert Opin Pharmacother, 18 (12): 1269-1277. [PMID:28697313]
3. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K. (2002)
Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver.
Hepatology, 36 (1): 164-72. [PMID:12085361]