Synonyms: IbTX
Compound class:
Peptide
Comment: From the venom gland of Mesobuthus tamulus (Eastern Indian scorpion). Iberiotoxin is selective for KCa1.1 channels that associate with β1, β2 and β3 regulatory subunits [1-3]. In contrast the KCa1.1 channels containing the β4 subunit that are found predominantly in the central nervous system are resistant to iberiotoxin inhibition [6]
|
|
References |
1. Li W, Gao SB, Lv CX, Wu Y, Guo ZH, Ding JP, Xu T. (2007)
Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons. J Cell Physiol, 212 (2): 348-57. [PMID:17523149] |
2. Lippiat JD, Standen NB, Harrow ID, Phillips SC, Davies NW. (2003)
Properties of BK(Ca) channels formed by bicistronic expression of hSloalpha and beta1-4 subunits in HEK293 cells. J Membr Biol, 192 (2): 141-8. [PMID:12682801] |
3. Löhn M, Lauterbach B, Haller H, Pongs O, Luft FC, Gollasch M. (2001)
beta(1)-Subunit of BK channels regulates arterial wall[Ca(2+)] and diameter in mouse cerebral arteries. J Appl Physiol, 91 (3): 1350-4. [PMID:11509535] |
4. Pethő Z, Tanner MR, Tajhya RB, Huq R, Laragione T, Panyi G, Gulko PS, Beeton C. (2016)
Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes. Arthritis Res Ther, 18 (1): 103. [PMID:27165430] |
5. Tanner MR, Pennington MW, Chamberlain BH, Huq R, Gehrmann EJ, Laragione T, Gulko PS, Beeton C. (2018)
Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis. J Pharmacol Exp Ther, 365 (2): 227-236. [PMID:29453198] |
6. Wang B, Jaffe DB, Brenner R. (2014)
Current understanding of iberiotoxin-resistant BK channels in the nervous system. Front Physiol, 5: 382. [PMID:25346692] |