- Guide to PHARMACOLOGY
Compound class: Natural product or derivative
Comment: Picrotoxin (C30H34O13) is an equimolar mixture of two compounds, picrotoxinin (C15H16O6) and picrotin (C15H18O7).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Das P, Bell-Horner CL, Machu TK, Dillon GH. (2003)
The GABA(A) receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors.
Neuropharmacology, 44 (4): 431-8. [PMID:12646280]
2. Das P, Dillon GH. (2003)
The 5-HT3B subunit confers reduced sensitivity to picrotoxin when co-expressed with the 5-HT3A receptor.
Brain Res Mol Brain Res, 119 (2): 207-12. [PMID:14625088]
3. Das P, Dillon GH. (2005)
Molecular determinants of picrotoxin inhibition of 5-hydroxytryptamine type 3 receptors.
J Pharmacol Exp Ther, 314 (1): 320-8. [PMID:15814570]