- Guide to PHARMACOLOGY
Compound class: Natural product or derivative
Comment: The INN-assigned compound is in complex with chloride. However, as our data is derived from use of the 'parent' compound rather than the complex, it is this structure we have chosen to display and to which the majority of the links in the table above refer to. There is some ambiguity as to the exact stereochemistry of alcuronium. CID 5360723 represents an alternative isomer.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Avlani VA, Gregory KJ, Morton CJ, Parker MW, Sexton PM, Christopoulos A. (2007)
Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands.
J Biol Chem, 282 (35): 25677-86. [PMID:17591774]
2. Jakubík J, Bacáková L, El-Fakahany EE, Tucek S. (1997)
Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
Mol Pharmacol, 52 (1): 172-9. [PMID:9224827]
3. Tränkle C, Weyand O, Voigtländer U, Mynett A, Lazareno S, Birdsall NJ, Mohr K. (2003)
Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
Mol Pharmacol, 64 (1): 180-90. [PMID:12815174]