- Guide to PHARMACOLOGY
Abbreviated name: FDP
Synonyms: farnesyl pyrophosphate (FPP)
Compound class: Metabolite or derivative
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Bang S, Yoo S, Yang TJ, Cho H, Hwang SW. (2010)
Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3.
J. Biol. Chem., 285 (25): 19362-71. [PMID:20395302]
2. Liliom K, Tsukahara T, Tsukahara R, Zelman-Femiak M, Swiezewska E, Tigyi G. (2006)
Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs.
Biochim. Biophys. Acta, 1761 (12): 1506-14. [PMID:17092771]
3. Oh DY, Yoon JM, Moon MJ, Hwang JI, Choe H, Lee JY, Kim JI, Kim S, Rhim H, O'Dell DK, Walker JM, Na HS, Lee MG, Kwon HB, Kim K, Seong JY. (2008)
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.
J. Biol. Chem., 283 (30): 21054-64. [PMID:18499677]
4. Williams JR, Khandoga AL, Goyal P, Fells JI, Perygin DH, Siess W, Parrill AL, Tigyi G, Fujiwara Y. (2009)
Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
J. Biol. Chem., 284 (25): 17304-19. [PMID:19366702]