farnesyl diphosphate

Ligand id: 2910

Name: farnesyl diphosphate

Abbreviated name: FDP

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 132.91
Molecular weight 382.13
XLogP 1.89
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Bang S, Yoo S, Yang TJ, Cho H, Hwang SW. (2010)
Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3.
J. Biol. Chem., 285 (25): 19362-71. [PMID:20395302]
2. Liliom K, Tsukahara T, Tsukahara R, Zelman-Femiak M, Swiezewska E, Tigyi G. (2006)
Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs.
Biochim. Biophys. Acta, 1761 (12): 1506-14. [PMID:17092771]
3. Oh DY, Yoon JM, Moon MJ, Hwang JI, Choe H, Lee JY, Kim JI, Kim S, Rhim H, O'Dell DK, Walker JM, Na HS, Lee MG, Kwon HB, Kim K, Seong JY. (2008)
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.
J. Biol. Chem., 283 (30): 21054-64. [PMID:18499677]
4. Williams JR, Khandoga AL, Goyal P, Fells JI, Perygin DH, Siess W, Parrill AL, Tigyi G, Fujiwara Y. (2009)
Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
J. Biol. Chem., 284 (25): 17304-19. [PMID:19366702]