leiurotoxin I   Click here for help

GtoPdb Ligand ID: 2316

Synonyms: Leiurotoxin-1 (LeTx1) | potassium channel toxin α-KTx 5.1 | scyllatoxin (ScyTx)
Compound class: Peptide or derivative
Comment: From Leiurus quinquestriatus hebraeus (Yellow scorpion)
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Hosseini R, Benton DC, Dunn PM, Jenkinson DH, Moss GW. (2001)
SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones.
J Physiol (Lond.), 535 (Pt 2): 323-34. [PMID:11533126]
2. Jäger H, Adelman JP, Grissmer S. (2000)
SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, Jurkat.
FEBS Lett, 469 (2-3): 196-202. [PMID:10713270]
3. Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG. (2001)
Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.
J Biol Chem, 276 (46): 43145-51. [PMID:11527975]
4. Strøbaek D, Jørgensen TD, Christophersen P, Ahring PK, Olesen SP. (2000)
Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells.
Br J Pharmacol, 129 (5): 991-9. [PMID:10696100]
5. Wittekindt OH, Visan V, Tomita H, Imtiaz F, Gargus JJ, Lehmann-Horn F, Grissmer S, Morris-Rosendahl DJ. (2004)
An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel.
Mol Pharmacol, 65 (3): 788-801. [PMID:14978258]