10-OBn-epi-ginkgolide C   Click here for help

GtoPdb Ligand ID: 1838

Abbreviated name: 10-OBn-epi-GC
Compound class: Natural product
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 158.05
Molecular weight 530.18
XLogP 0.7
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES O=C1OC2C3(C1OCc1ccccc1)C(C(C1C43C(O2)(C(=O)O1)C1(C(C4O)OC(=O)C1C)O)O)C(C)(C)C
Isomeric SMILES O=C1OC2C3([C@H]1OCc1ccccc1)C([C@@H](C1C43[C@@](O2)(C(=O)O1)[C@@]1([C@H](C4O)OC(=O)C1C)O)O)C(C)(C)C
InChI InChI=1S/C27H30O11/c1-11-19(30)35-17-15(29)25-16-13(28)14(23(2,3)4)24(25)18(34-10-12-8-6-5-7-9-12)20(31)37-22(24)38-27(25,21(32)36-16)26(11,17)33/h5-9,11,13-18,22,28-29,33H,10H2,1-4H3/t11?,13-,14?,15?,16?,17-,18-,22?,24?,25?,26+,27-/m0/s1
InChI Key YPOMAFCMSAKBRX-CLNXZACASA-N
References
1. Vogensen SB, Stromgaard K, Shindou H, Jaracz S, Suehiro M, Ishii S, Shimizu T, Nakanishi K. (2003)
Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists.
J Med Chem, 46: 601-608. [PMID:12570381]