factor XIIa blocking antibody 3F7

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Ligands
factor XIIa blocking antibody 3F7

GtoPdb Ligand ID: 12771

Comment: This recombinant fully human FXIIa-blocking antibody abolishes FXIIa enzymatic activity [2]. Inhibition of FXIIa by 3F7 offers a mechanism as a safe anticoagulant that prevents thrombosis without increasing therapy-associated bleeding [1]. Antibody 3F7 also mediates an anti-inflammatory effect (via the bradykinin-producing kallikrein-kinin system) that may be of clinical utility in acute edema disorders.

References
1. Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P et al.. (2014) A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk. Sci Transl Med, 6 (222): 222ra17. [PMID:24500405]
2. Worm M, Köhler EC, Panda R, Long A, Butler LM, Stavrou EX, Nickel KF, Fuchs TA, Renné T. (2015) The factor XIIa blocking antibody 3F7: a safe anticoagulant with anti-inflammatory activities. Ann Transl Med, 3 (17): 247. [PMID:26605293]

References

1. Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P et al.. (2014)
A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk.
Sci Transl Med, 6 (222): 222ra17. [PMID:24500405]

2. Worm M, Köhler EC, Panda R, Long A, Butler LM, Stavrou EX, Nickel KF, Fuchs TA, Renné T. (2015)
The factor XIIa blocking antibody 3F7: a safe anticoagulant with anti-inflammatory activities.
Ann Transl Med, 3 (17): 247. [PMID:26605293]