ASC06-IgG1   Click here for help

GtoPdb Ligand ID: 12564

Compound class: Antibody
Comment: ASC06-IgG1 is a antibody that inhibits ASIC1a channel activity [1]. It binds to the structurally intact channel in the upper part of the extracellular domain with substantial contact on the finger domain and is highly selective for ASIC1a over other subtypes.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Qiang M, Dong X, Zha Z, Zuo XK, Song XL, Zhao L, Yuan C, Huang C, Tao P, Hu Q et al.. (2018)
Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death.
Proc Natl Acad Sci U S A, 115 (32): E7469-E7477. [PMID:30042215]