tepoditamab   Click here for help

GtoPdb Ligand ID: 10353

Synonyms: MCLA-117 | MCLA117 | PB9122
Immunopharmacology Ligand
Compound class: Antibody
Comment: Tepoditamab (MCLA-117) is a bispecific monoclonal antibody that binds CLEC12A on myeloid cells and CD3ε on cytotoxic T cells. It is being developed by Merus as a novel therapy for acute myeloid leukemia (AML) [1].
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1. Van Loo PF, Doornbos R, Dolstra H, Shamsili S, Bakker L. (2015)
Preclinical Evaluation of MCLA117, a CLEC12AxCD3 Bispecific Antibody Efficiently Targeting a Novel Leukemic Stem Cell Associated Antigen in AML.
Blood, 126 (23): 325.