Ligand id: 2739

Name: lovastatin

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 72.83
Molecular weight 404.26
XLogP 4.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
Evidence suggests that statins have immunomodulatory activity. The anti-inflammatory effect of lovastatin has been attributed to its ability to inhibit the expression of pro-inflammatory mediators (iNOS, TNF-α), as well as the suppression of HDAC1 expression, PI3K/Akt phosphorylation and NF-κB translocation [3].