penpulimab   Click here for help

GtoPdb Ligand ID: 12347

Synonyms: AK-105 | AK105
Approved drug Immunopharmacology Ligand
penpulimab is an approved drug (China (2021))
Compound class: Antibody
Comment: Penpulimab (AK-105) is a chimeric IgG1κ programmed cell death 1 (PD-1) monoclonal antibody [2]. Its engineered Fc structure means that it does not interact with Fcγ receptors and therefore it does not induce immune cell (macrophage) effector functions (antibody-dependent cell-mediated cytotoxicity/ADCC, antibody-dependent cellular phagocytosis/ADCP, antibody-dependent cytokine release/ADCR). Penpulimab binds to an epitope in human PD-1's N-glycosylation site (at residue N58).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
Penpulimab blocks the inhibitory immune checkpoint interaction between PD-1 and its ligands PD-L1 and PD-L2 to promote an antitumour immune response.