- Guide to PHARMACOLOGY
Synonyms: LY-2439821 | LY2439821 | Taltz®
ixekizumab is an approved drug (FDA & EMA (2016))
Compound class: Antibody
Comment: Ixekizumab binds to IL-17A and blocks its action.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. A protein BLAST search using the variable region of the heavy chain of ixekizumab identifies this as sequence 118 from patent US7838638 . In this patent binding affinity data for human IL-17 is provided for several antibody clones, but it does not specify which was chosen as ixekizumab, although mAbs 126, 121 and 104 did undergo additional experimental investigations.
|No information available.|
|Summary of Clinical Use|
|Ixekizumab is approved for the treatment of psoriasis. Positive results from a Phase 2 study are reported in , and Phase 3 results are reviewed in . In March 2016, the US FDA approved ixekizumab for the treatment of moderate-to-severe plaque psoriasis. The EMA granted marketing authorisation in April 2016.
Phase 3 results following 60 weeks of treatment are reported in , showing longer term efficacy (with ~80% of patients seeing at least a 75% improvement in their skin symptoms at 60 weeks).
|Mechanism Of Action and Pharmacodynamic Effects|
|The IL-17 pathway is an established driver of psoriasis pathogenesis [7,9]. Ixekizumab effectively neutralises circulating IL-17A and reduces IL-17-induced pro-inflammatory signalling. This leads to an improvement in clinical disease symptoms. .|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)
European Medicines Agency (EMA)