- Guide to PHARMACOLOGY
Compound class: Natural product or derivative
Comment: Curcumin's physicochemical properties imply that it is an implausible clinical lead . It is unstable, reactive, and nonbioavailable, and has been identified as having attributes of both PAINS (pan-assay interference compounds) and IMPS (invalid metabolic panaceas) compounds.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|Although a large number of clinical studies have been initiated to evaluate curcumin as a human disease therapeutic, none have been successful. This is most likely because the working hypotheses have been built upon weak and unconvincing in vitro and in vivo evidence .|