5-aminolevulinic acid   Click here for help

GtoPdb Ligand ID: 4784

Synonyms: 5-aminolevulinate | Ameluz® | D-aminolevulinic acid | Gliolan® | Levulan®
Approved drug PDB Ligand
5-aminolevulinic acid is an approved drug (FDA (1999)m EMA (2007))
Comment: Approved as aminolevulinic acid
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 80.39
Molecular weight 131.06
XLogP -1.55
No. Lipinski's rules broken 0
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Canonical SMILES NCC(=O)CCC(=O)O
InChI InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
No information available.
Summary of Clinical Use Click here for help
May be used as a topical agent in photochemotherapy treatment for actinic keratosis. Gliolan® (for oral solution) is indicated for visualisation of malignant tissue during surgery for malignant glioma.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The mechanism of action is complex. Please see the DrugBank link on the Summary tab of this ligand page for a detailed explanation. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
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