- Guide to PHARMACOLOGY
Synonyms: 5-aminolevulinate | Ameluz® | D-aminolevulinic acid | Gliolan® | Levulan®
5-aminolevulinic acid is an approved drug (FDA (1999)m EMA (2007))
Compound class: Metabolite or derivative
Comment: Approved as aminolevulinic acid
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.
|Summary of Clinical Use
|May be used as a topical agent in photochemotherapy treatment for actinic keratosis. Gliolan® (for oral solution) is indicated for visualisation of malignant tissue during surgery for malignant glioma.
|Mechanism Of Action and Pharmacodynamic Effects
|The mechanism of action is complex. Please see the DrugBank link on the Summary tab of this ligand page for a detailed explanation. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)
European Medicines Agency (EMA)