melatonin   Click here for help

GtoPdb Ligand ID: 224

Abbreviated name: MLT
Synonyms: Circadin®
Approved drug PDB Ligand Immunopharmacology Ligand
melatonin is an approved drug (EMA (2007))
Comment: Melatonin is a hormone involved in regulating circadian rhythms in animals. Melatonin activates a family of melatonin receptors.

SARS-CoV-2 and COVID-19: The effect of viral infection (including by influenza and SARS-CoV-2) on the melatonergic pathway, and how this might modulate the inflammatory response was reviewed by Anderson and Reiter in May 2020 [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 54.12
Molecular weight 232.12
XLogP 1.6
No. Lipinski's rules broken 0
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Canonical SMILES COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2
Isomeric SMILES COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2
InChI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
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Summary of Clinical Use Click here for help
Melatonin is used in the treatment of insomnia and is also a powerful antioxidant. It is available without a prescription as an over-the-counter dietary supplement in the US. In the EU it is a prescription-only medicine.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Melatonin agonists act to shorten sleep onset latency and advance the circadian phase, to promote sleep.
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