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nivolumab   Click here for help

GtoPdb Ligand ID: 7335

Synonyms: BMS-936558 | MDX-1106 | ONO-4538 | Opdivo®
Approved drug Immunopharmacology Ligand
nivolumab is an approved drug (FDA (2014), EMA (2015))
Compound class: Antibody
Comment: Nivolumab is an IgG4 kappa immunoglobulin that is selective for PD-1, an immune-checkpoint receptor expressed on activated T-cells, monocytes, B-cells, natural killer (NK) T-cells, and dendritic cells [12]. This monoclonal is produced in Chinese hamster ovary cells by recombinant DNA technology. Nivolumab is an immuno-oncology drug.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Sequence analysis of the light and heavy chain variable region peptides of nivolumab shows exact matches with claimed peptide sequences of monoclonal 5C4 contained in patent WO2006121168 [10].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: nivolumab

Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
programmed cell death 1 (CD279) Primary target of this compound Hs Antibody Binding 9.1 pKd - 5,9-10
⤷ pKd 9.1 (Kd 7.3x10-10 M) [5,9-10]
programmed cell death 1 (CD279) Primary target of this compound Hs Antibody Binding 10.3 pEC50 - 20
⤷ pEC50 10.3 (EC50 5.3x10-11 M) [20]
programmed cell death 1 (CD279) Monkey Antibody Binding 9.4 pEC50 - 20
⤷ pEC50 9.4 (EC50 4x10-10 M) [20]