omalizumab   Click here for help

GtoPdb Ligand ID: 6890

Synonyms: IGE25 | olizumab | R03DX05 | RG-3648 | rhumab-E25 | Xolair®
Approved drug Immunopharmacology Ligand
omalizumab is an approved drug (FDA (2003), EMA (2005))
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Peptide sequence analysis reveals that omalizumab is clone e25 in patent US5994511 [3].
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Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
immunoglobulin heavy constant epsilon Primary target of this compound Hs Antibody Binding 7.6 – 8.2 pKd - 1,3
pKd 8.2 (Kd 6.98x10-9 M) [1]
Description: In vitro binding affinity
pKd 7.6 (Kd 2.6x10-8 M) [3]
Description: F(ab) apparent binding affinity of e25 measured by surface plasmon resonance