ipilimumab   Click here for help

GtoPdb Ligand ID: 6888

Synonyms: MDX-010 | MDX-101 | MDX-CTLA-4 | Yervoy®
Approved drug Immunopharmacology Ligand
ipilimumab is an approved drug (FDA and EMA (2011))
Compound class: Antibody
Comment: Ipilimumab is an anti-CTLA-4 monoclonal antibody. It is likely the subject of patent WO2001014424 [4], as antibody 10D1 which was investigated further, claimed in patent EP1503794 [1]. Ipilimumab is an immune checkpoint inhibitor.
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Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
cytotoxic T-lymphocyte-associated protein 4 (CD152) Primary target of this compound Hs Antibody Binding >9.0 pKd - 4
pKd >9.0 (Kd <1x10-9 M) [4]