folic acid

Ligand id: 4563

Name: folic acid

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 6
Rotatable bonds 10
Topological polar surface area 213.28
Molecular weight 441.14
XLogP -1.88
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Reduced folate transporter 1 2
Proton-coupled folate transporter 1
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Substrates at Proton-coupled folate transporter folic acid (1.3µM) > heme (>100 µM) 1
Ligand mentioned in the following text fields
SLC19 family of vitamin transporters overview
SLC46 family of folate transporters overview