sibeprenlimab   Click here for help

GtoPdb Ligand ID: 12102

Synonyms: VIS-649 | VIS649
Immunopharmacology Ligand
Compound class: Antibody
Comment: Sibeprenlimab (VIS-649) is a fully humanized IgG2κ monoclonal antibody that targets the B-cell growth factor APRIL (TNFSF13) [1,4]. The antibody binds with high affinity to human trimeric APRIL, and potently blocks APRIL binding to its receptors TACI (transmembrane activator and CAML interactor) and BCMA (B-cell maturation antigen). It was developed by Visterra for anti-inflammatory potential.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
APRIL Hs Antibody Binding 12.0 pKd - 4
⤷ pKd 12.0 (Kd 9.5x10-13 M) [4]
Description: Binding affinity determined by surface plasmon resonance (SPR)