PF-07062119   Click here for help

GtoPdb Ligand ID: 11125

Compound class: Antibody
Comment: PF-07062119 is a bispecific T cell-engaging (BiTE) monoclonal antibody that is being developed by Pfizer [1]. It simultaneously binds to CD3ε on T cells and GUCY2C-positive cancer cells.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
PF-07062119 distributes selectively to GUCY2C-positive tumours in vivo and it induces potent T-cell-mediated efficacy in in vivo colorectal cancer human xenograft tumour models [1].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Guanylyl cyclase-C Monkey Antibody Binding 8.5 pKd - 1
⤷ pKd 8.5 (Kd 3.01x10-9 M) [1]
Description: Binding affinity for cynomolgus GUCY2C determined by SPR BIACore assay.
Guanylyl cyclase-C Hs Antibody Binding 8.1 pKd - 1
⤷ pKd 8.1 (Kd 7.47x10-9 M) [1]
Description: Binding affinity determined by SPR BIACore assay.
Guanylyl cyclase-C Mm Antibody Binding 7.8 pKd - 1
⤷ pKd 7.8 (Kd 1.727x10-8 M) [1]
Description: Binding affinity determined by SPR BIACore assay.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD3e Hs Antibody Binding 7.6 pKd - 1
⤷ pKd 7.6 (Kd 2.397x10-8 M) [1]
Description: Binding affinity for human CD3ε in a SPR BIACore assay.
CD3e Monkey Antibody Binding 7.6 pKd - 1
⤷ pKd 7.6 (Kd 2.412x10-8 M) [1]
Description: Binding affinity for cynomolgus CD3ε in a SPR BIACore assay.