- Guide to PHARMACOLOGY
Synonyms: AMG203  | MT203
Compound class: Antibody
Comment: Namilumab (AMG203, MT203) is an IgG1κ anti-macrophage colony-stimulating factor (GM-CSF; CSF2) monoclonal antibody . It is being developed by Micromet and Nycomed for the treatment of autoimmune and chronic inflammatory diseases.
Peptide sequences and structural information for this antibody are available from its IMGT/mAb-DB entry.
|Namilumab does not bind to either of the other colony-stimulating factors (G-CSF or M-CSF) . It potently neutralises recombinant human GM-CSF produced in E. coli and yeast expression systems, and endogenous GM-CSF from human bronchial epithelial cells. It also binds and neutralises macaque GM-CSF.|
|Selectivity at ligand targets|
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