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tetomilast   Click here for help

GtoPdb Ligand ID: 9877

Synonyms: compound 19f [PMID: 7830278] | OPC-6535 | OPC6535
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Tetomilast is a PDE4 inhibitor. Inhibition of PDE4 blocks the oxidative burst in human neutrophils, which is a major mediator of tissue injury in inflammatory diseases. Tetomilast (OPC-6535) was originally identified as an inhibitor of superoxide production by human neutrophils [1]. The clinical potential of PDE4 inhibition in inflammatory bowel disease was reviewed by Salari and Abdollahiin 2012 [2].

tetomilast is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 109.78
Molecular weight 370.1
XLogP 1.21
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCOc1cc(ccc1OCC)c1scc(n1)c1cccc(n1)C(=O)O
Isomeric SMILES CCOc1cc(ccc1OCC)c1scc(n1)c1cccc(n1)C(=O)O
InChI InChI=1S/C19H18N2O4S/c1-3-24-16-9-8-12(10-17(16)25-4-2)18-21-15(11-26-18)13-6-5-7-14(20-13)19(22)23/h5-11H,3-4H2,1-2H3,(H,22,23)
InChI Key XDBHURGONHZNJF-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
8430 tetomilast
Synonyms Click here for help
compound 19f [PMID: 7830278] | OPC-6535 | OPC6535
Database Links Click here for help
CAS Registry No. 145739-56-6 (source: WHO INN record)
ChEMBL Ligand CHEMBL332750
DrugBank Ligand DB05298
GtoPdb PubChem SID 363894171
PubChem CID 3025803
Search Google for chemical match using the InChIKey XDBHURGONHZNJF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone XDBHURGONHZNJF
Search PubMed clinical trials tetomilast
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Search PubMed titles/abstracts tetomilast
UniChem Compound Search for chemical match using the InChIKey XDBHURGONHZNJF-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey XDBHURGONHZNJF-UHFFFAOYSA-N

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MedChemExpress
Tetomilast (links to external site)
Cat. No. HY-105092