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growth differentiation factor 15   Click here for help

GtoPdb Ligand ID: 9735

Abbreviated name: GDF15
Synonyms: macrophage inhibitory cytokine-1 | MIC-1 | MIC1 | PTGFB
Compound class: Endogenous peptide in human, mouse or rat
Comment: GDF15 is a TGFβ family protein. A commentary on the function(s) of GDF15 was published in 2017 [8]. Experimental evidence indicates that the biological effects of GDF15 are mediated by signalling via a GFRAL/Ret complex [4,7-8,10].
GDF15 promotes nausea and vomiting (emesis), and elevated levels have been associated with pregnancy-induced morning sickness and the risk of hyperemesis gravidarum [5]. GDF15/GFRAL signalling is also a major driver of nausea, elevated catabolism and weight loss in patients with advanced cancer [2-3]. Hence, disrupting the formation or function of the GDF15/GFRAL/Ret complex is a mechanism being explored for the mitigation of chemotherapy-induced nausea, cachexia and malaise [1,6,9].
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
macrophage inhibitory cytokine-1 | MIC-1 | MIC1 | PTGFB
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
GDF15 growth differentiation factor 15 Human growth/differentiation factor 15 preproprotein growth/differentiation factor 15, placental bone morphogenetic protein, placental TGF-beta, PTGF-beta
Database Links Click here for help
Ensembl Gene ENSG00000130513 (Hs)
GtoPdb PubChem SID 354702211
Human Protein Atlas ENSG00000130513 (Hs)
OMIM 605312 (Hs)
UniProtKB Q99988 (Hs)