olamkicept 
GtoPdb Ligand ID: 9729
|
Synonyms: FE 999301 | FE-301 | FE-999301 | TJ301
Compound class:
Peptide
Comment: Olamkicept is a recombinant protein that fuses the extracellular domain of the signal transducing subunit of the IL-6 receptor, IL-6Rβ (glycoprotein 130, gp130), to a human IgG Fc fragment [3]. The full construct is a dimer of covalently linked identical peptide chains. Mechanistically olamkicept acts as an inhibitor of the IL-6 signalling pathway. Olamkicept inhibits trans signalling by the soluble IL-6 receptor (sIL-6R) [1], a mechanism that is involved in human inflammatory and autoimmune diseases [2]. It is hypothesised to be clinically effective in reducing disease signs and symptoms whilst not being detrimental to the role of IL-6 in the acute immune response to infection.
|
For advanced searching click here to open chemical structure editor
Other Similar Sequences  |
|
| IL-22 {Sp: Human} |
TargetsInterleukin-22α1/10β heteromer |
| dulaglutide | |
| evorpacept |
TargetsCD47 |
| ontorpacept |
TargetsCD47 |
| efmarodocokin alfa |
TargetsInterleukin-22α1/10β heteromer |
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License