verinurad   Click here for help

GtoPdb Ligand ID: 9327

Synonyms: RDEA-3170 | RDEA3170
PDB Ligand
Compound class: Synthetic organic
Comment: Verinurad (RDEA3170) is an investigational selective uric acid reabsorption inhibitor, functionally inhibiting the URAT1 (SLC22A12) transporter and being investigated for clinical efficacy in controlling uric acid levels in patients with gout. URAT1 is the renal transporter that regulates uric acid excretion from the body. Verinurad is structurally related to lesinurad (RDEA594), a URAT1 inhibitor already approved for treating hyperuricemia in gout.

verinurad is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 99.28
Molecular weight 348.09
XLogP 4.05
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES N#Cc1ccc(c2c1cccc2)c1cnccc1SC(C(=O)O)(C)C
Isomeric SMILES N#Cc1ccc(c2c1cccc2)c1cnccc1SC(C(=O)O)(C)C
InChI InChI=1S/C20H16N2O2S/c1-20(2,19(23)24)25-18-9-10-22-12-17(18)16-8-7-13(11-21)14-5-3-4-6-15(14)16/h3-10,12H,1-2H3,(H,23,24)
InChI Key YYBOLPLTQDKXPM-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
No information available.
Summary of Clinical Use Click here for help
Verinurad (RDEA3170) has completed Phase 2 clinical trials as monotherapy and in combination with either febuxostat or allopurinol (both of these are xanthine dehydrogenase inhibitors which inhibit the production of uric acid) in patients with gout.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Inhibition of URAT1 improves uric acid excretion, thereby lowering uric acid levels and reducung the cause and symptoms of gout.