leucomethylthioninium   Click here for help

GtoPdb Ligand ID: 9274

Synonyms: leuco-methylthioninium | LMTM | LMTX | TRx-0237 | TRx0237
Approved drug
leucomethylthioninium is an approved drug
Compound class: Synthetic organic
Comment: Leucomethylthioninium complexed with bromide or methane sulfonate (LMTX) was designed as a methylthioninium chloride (MTC, or methylene blue) analogue with improved pharmacokinetic properties [1]. MTC and LMTX are tau aggregation inhibitors with potential in Alzheimer's disease (AD) and other tau-opathies. We believe this is the compound being investigated in Phase 3 clinical trials as TRx0237.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 46.21
Molecular weight 287.15
XLogP 2.68
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C[NH+](c1ccc2c(c1)Sc1c(N2)ccc(c1)[NH+](C)C)C
Isomeric SMILES C[NH+](c1ccc2c(c1)Sc1c(N2)ccc(c1)[NH+](C)C)C
InChI InChI=1S/C16H19N3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13/h5-10,17H,1-4H3/p+2
InChI Key QTWZICCBKBYHDM-UHFFFAOYSA-P

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. China NMPA (2024)
IUPAC Name Click here for help
N3,N3,N7,N7-tetramethyl-10H-phenothiazine-3,7-bis(aminium)
Synonyms Click here for help
leuco-methylthioninium | LMTM | LMTX | TRx-0237 | TRx0237
Database Links Click here for help
GtoPdb PubChem SID 318164793
PubChem CID 122173994
Search Google for chemical match using the InChIKey QTWZICCBKBYHDM-UHFFFAOYSA-P
Search Google for chemicals with the same backbone QTWZICCBKBYHDM
UniChem Compound Search for chemical match using the InChIKey QTWZICCBKBYHDM-UHFFFAOYSA-P
UniChem Connectivity Search for chemical match using the InChIKey QTWZICCBKBYHDM-UHFFFAOYSA-P