IL-34

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Ligands
IL-34 (Human)

GtoPdb Ligand ID: 8975

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-34 is an endogenous ligand of the receptor tyrosine kinase, colony stimulating factor 1 receptor (CSF1R) [3]. It is a homodimeric cytokine.

Species: Human

References
1. Chang EJ, Lee SK, Song YS, Jang YJ, Park HS, Hong JP, Ko AR, Kim DY, Kim JH, Lee YJ et al.. (2014) IL-34 is associated with obesity, chronic inflammation, and insulin resistance. J Clin Endocrinol Metab, 99 (7): E1263-71. [PMID:24712570]
2. Franzè E, Monteleone I, Cupi ML, Mancia P, Caprioli F, Marafini I, Colantoni A, Ortenzi A, Laudisi F, Sica G et al.. (2015) Interleukin-34 sustains inflammatory pathways in the gut. Clin Sci, 129 (3): 271-80. [PMID:25800277]
3. Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G, Zhou A, Behrens D et al.. (2008) Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science, 320 (5877): 807-11. [PMID:18467591]

References

1. Chang EJ, Lee SK, Song YS, Jang YJ, Park HS, Hong JP, Ko AR, Kim DY, Kim JH, Lee YJ et al.. (2014)
IL-34 is associated with obesity, chronic inflammation, and insulin resistance.
J Clin Endocrinol Metab, 99 (7): E1263-71. [PMID:24712570]

2. Franzè E, Monteleone I, Cupi ML, Mancia P, Caprioli F, Marafini I, Colantoni A, Ortenzi A, Laudisi F, Sica G et al.. (2015)
Interleukin-34 sustains inflammatory pathways in the gut.
Clin Sci, 129 (3): 271-80. [PMID:25800277]

3. Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G, Zhou A, Behrens D et al.. (2008)
Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.
Science, 320 (5877): 807-11. [PMID:18467591]