tanezumab   Click here for help

GtoPdb Ligand ID: 8415

Synonyms: PF-04383119 | PF04383119 | RN624
Compound class: Antibody
Comment: Tanezumab is an investigational monoclonal antibody targeting nerve growth factor (NGF). NGF is a neurotrophin that regulates the development and survival of a select population of neurons through the binding and activation of the neurotrophic receptor tyrosine kinase 1 (TrkA receptor). Elevated levels of NGF have been associated with painful pathologies including diabetic neuropathy, fibromyalgia and osteoarthritis, and cancer apin. Inhibition of NGF signalling has been explored for anti-pain potential.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. BLAST peptide sequence analysis reveals identical sequences are claimed in patent US7449616.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
NGF Primary target of this compound Hs Antibody Binding 10.1 pKd - 8
⤷ pKd 10.1 (Kd 7x10-11 M) [8]
Description: Affinity of NGF of antibody E3 for human NGF.