NGF   Click here for help

GtoPdb Ligand ID: 5026

Synonyms: beta-nerve growth factor | beta-NGF | Oxervate® | Sentinel®
Approved drug
NGF is an approved drug (EMA (2017), FDA (2018))
Compound class: Endogenous peptide in human, mouse or rat
Comment: Recombinant NGF (cenegermin, also known as cenegermin-bkbj) is used clinically as a peripherally selective agonist of TrkA and LNGFR. Note that the recombinant peptide is two amino acids shorter than the endogenous peptide, with the carboxy-terminal RA (Arg-Ala) removed.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes. EMA (2017)  |  FDA (2018)
International Nonproprietary Names Click here for help
INN number INN
10381 cenegermin
Synonyms Click here for help
beta-nerve growth factor | beta-NGF | Oxervate® | Sentinel®
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
NGF nerve growth factor Human prepro-beta-nerve growth factor nerve growth factor (beta polypeptide), NGFB
Database Links Click here for help
CATH/Gene3D 2.10.90.10
Ensembl Gene ENSG00000134259 (Hs)
GtoPdb PubChem SID 178101723
Human Protein Atlas ENSG00000134259 (Hs)
Search PubMed clinical trials cenegermin
Search PubMed titles cenegermin
Search PubMed titles/abstracts cenegermin
UniProtKB P01138 (Hs)
Wikipedia Nerve_growth_factor