mirogabalin   Click here for help

GtoPdb Ligand ID: 8303

Synonyms: DS-5565 | DS5565
Approved drug PDB Ligand
mirogabalin is an approved drug
Compound class: Synthetic organic
Comment: Mirogabalin (DS-5565) is a gabapentinoid that binds to the α2δ subunit of the voltage-gated calcium channels, with some selectivity for the α2δ-1 channel complex [2]. It is proposed to treat chronic peripheral pain [1,3-4,6].

mirogabalin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 63.32
Molecular weight 209.14
XLogP 1.5
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCC1=CC2C(C1)CC2(CN)CC(=O)O
Isomeric SMILES CCC1=C[C@@H]2[C@H](C1)C[C@]2(CN)CC(=O)O
InChI InChI=1S/C12H19NO2/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15)/t9-,10-,12-/m1/s1
InChI Key FTBQORVNHOIASH-CKYFFXLPSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Baba M, Takatsuna H, Matsui N, Ohwada S. (2020)
Mirogabalin in Japanese Patients with Renal Impairment and Pain Associated with Diabetic Peripheral Neuropathy or Post-Herpetic Neuralgia: A Phase III, Open-Label, 14-Week Study.
J Pain Res, 13: 1811-1821. [PMID:32765056]
2. Calandre EP, Rico-Villademoros F, Slim M. (2016)
Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use.
Expert Rev Neurother, 16 (11): 1263-1277. [PMID:27345098]
3. Saeki K, Yasuda SI, Kato M, Kano M, Domon Y, Arakawa N, Kitano Y. (2019)
Analgesic effects of mirogabalin, a novel ligand for α2δ subunit of voltage-gated calcium channels, in experimental animal models of fibromyalgia.
Naunyn Schmiedebergs Arch Pharmacol, 392 (6): 723-728. [PMID:30770951]
4. Sawa A, Bando H, Sato R, Matsuo T, Okazaki M, Hashimoto S, Iguchi-Manaka A, Hara H. (2025)
Efficacy and Safety of Mirogabalin Therapy for Paclitaxel-Induced Peripheral Neuropathy (MICHEL Study): A Pilot Study.
Oncology,: 1-12 [Epub ahead of print]. [PMID:39900018]
5. Yamamura N, Mikkaichi T, Itokawa KI, Hoshi M, Damme K, Geigner S, Baumhauer C. (2022)
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K.
Xenobiotica, 52 (9-11): 997-1009. [PMID:36170033]
6. Yang F, Wang Y, Zhang M, Yu S. (2024)
Mirogabalin as a novel calcium channel α2δ ligand for the treatment of neuropathic pain: a review of clinical update.
Front Pharmacol, 15: 1491570. [PMID:39650158]