dexbrompheniramine   Click here for help

GtoPdb Ligand ID: 7588

Synonyms: D-brompheniramine | Disomer®
Approved drug
dexbrompheniramine is an approved drug (FDA)
Compound class: Synthetic organic
Comment: Chemically, dexbrompheniramine is the pharmacologically active dextrorotatory isomer of brompheniramine.

dexbrompheniramine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 16.13
Molecular weight 318.07
XLogP 3.41
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CN(CCC(c1ccccn1)c1ccc(cc1)Br)C
Isomeric SMILES CN(CC[C@H](c1ccccn1)c1ccc(cc1)Br)C
InChI InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
InChI Key ZDIGNSYAACHWNL-HNNXBMFYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. FDA (0)
Withdrawn drug? Yes
IUPAC Name Click here for help
(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
International Nonproprietary Names Click here for help
INN number INN
907 dexbrompheniramine
Synonyms Click here for help
D-brompheniramine | Disomer®
Database Links Click here for help
CAS Registry No. 132-21-8
ChEBI CHEBI:59269
ChEMBL Ligand CHEMBL1201287
DrugBank Ligand DB00405
DrugCentral Ligand 830
GtoPdb PubChem SID 223365923
PubChem CID 16960
Search Google for chemical match using the InChIKey ZDIGNSYAACHWNL-HNNXBMFYSA-N
Search Google for chemicals with the same backbone ZDIGNSYAACHWNL
Search PubMed clinical trials dexbrompheniramine
Search PubMed titles dexbrompheniramine
Search PubMed titles/abstracts dexbrompheniramine
UniChem Compound Search for chemical match using the InChIKey ZDIGNSYAACHWNL-HNNXBMFYSA-N
UniChem Connectivity Search for chemical match using the InChIKey ZDIGNSYAACHWNL-HNNXBMFYSA-N
Wikipedia Dexbrompheniramine

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MedChemExpress
Dexbrompheniramine (links to external site)
Cat. No. HY-A0191
(Same InChi Key)