Synonyms: RTA 408 | RTA-408 | Skyclarys®
omaveloxolone is an approved drug (FDA (2023), EMA (2024))
Compound class:
Synthetic organic
Comment: Chemically omaveloxolone (RTA 408) is a second generation synthetic oleanane triterpenoid compound, which structurally resembles bardoxolone, and has difluoropropanamide replacing the carboxylic acid moiety.
This compound is claimed in patent WO2013163344A1. The chemical structure represented above, was drawn from this patent, but structures with alternate stereochemistry are submitted in PubChem. Pharmacologically omaveloxolone activates the Nrf2 transcription factor, to modulate expression of proteins that have antioxidative, anti-inflammatory, and mitochondrial bioenergetic activities [6-7]. |
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Classification ![]() |
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Compound class | Synthetic organic |
Approved drug? | Yes. FDA (2023) |
IUPAC Name ![]() |
N-[(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicen-4a-yl]-2,2-difluoropropanamide |
International Nonproprietary Names ![]() |
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INN number | INN |
10135 | omaveloxolone |
Synonyms ![]() |
RTA 408 | RTA-408 | Skyclarys® |
Database Links ![]() |
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GtoPdb PubChem SID | 223365909 |
PubChem CID | 71811910 |
Search Google for chemical match using the InChIKey | RJCWBNBKOKFWNY-IDPLTSGASA-N |
Search Google for chemicals with the same backbone | RJCWBNBKOKFWNY |
Search PubMed clinical trials | omaveloxolone |
Search PubMed titles | omaveloxolone |
Search PubMed titles/abstracts | omaveloxolone |
UniChem Compound Search for chemical match using the InChIKey | RJCWBNBKOKFWNY-IDPLTSGASA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RJCWBNBKOKFWNY-IDPLTSGASA-N |
Wikipedia | RTA 408 |
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Omaveloxolone (links to external site)
Cat. No. HY-12212 |