florbetapir   Click here for help

GtoPdb Ligand ID: 7344

Synonyms: AMYViD® | AV-45 | florbetapir (18F)
Approved drug  Ligand is labelled  Ligand is radioactive
florbetapir is an approved drug (FDA (2012), EMA (2013))
Compound class: Synthetic organic
Comment: Florbetapir F18 is a molecular imaging agent (diagnostic radiopharmaceutical) that binds to β-amyloid aggregates in Alzheimer's brains.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 52.61
Molecular weight 360.18
XLogP 3.73
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES FCCOCCOCCOc1ccc(cn1)C=Cc1ccc(cc1)NC
Isomeric SMILES [18F]CCOCCOCCOc1ccc(cn1)/C=C/c1ccc(cc1)NC
InChI InChI=1S/C20H25FN2O3/c1-22-19-7-4-17(5-8-19)2-3-18-6-9-20(23-16-18)26-15-14-25-13-12-24-11-10-21/h2-9,16,22H,10-15H2,1H3/b3-2+/i21-1
InChI Key YNDIAUKFXKEXSV-CRYLGTRXSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. FDA (2012)  |  EMA (2013)
IUPAC Name Click here for help
4-[(E)-2-[6-(2-{2-[2-(18F)fluoroethoxy]ethoxy}ethoxy)pyridin-3-yl]ethenyl]-N-methylaniline
International Nonproprietary Names Click here for help
INN number INN
9193 florbetapir (18F)
Synonyms Click here for help
AMYViD® | AV-45 | florbetapir (18F)
Database Links Click here for help
CAS Registry No. 956103-76-7 (source: SciFinder)
ChEMBL Ligand CHEMBL1774461
DrugCentral Ligand 4285
GtoPdb PubChem SID 178103916
PubChem CID 24822371
Search Google for chemical match using the InChIKey YNDIAUKFXKEXSV-CRYLGTRXSA-N
Search Google for chemicals with the same backbone YNDIAUKFXKEXSV
Search PubMed clinical trials florbetapir
Search PubMed titles florbetapir
Search PubMed titles/abstracts florbetapir
UniChem Compound Search for chemical match using the InChIKey YNDIAUKFXKEXSV-CRYLGTRXSA-N
UniChem Connectivity Search for chemical match using the InChIKey YNDIAUKFXKEXSV-CRYLGTRXSA-N
Wikipedia Florbetapir