inamrinone   Click here for help

GtoPdb Ligand ID: 7202

Synonyms: amrinone lactate | Inocor® | WIN-40680
Approved drug
inamrinone is an approved drug (FDA (1984))
Compound class: Synthetic organic
Comment: Inamrinone is a phosphodiesterase inhibitor.
Marketed formulations may contain inamrinone lactate (PubChem CID 3035194).
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: inamrinone

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 72.03
Molecular weight 187.07
XLogP 1.39
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES Oc1ncc(cc1N)c1ccncc1
Isomeric SMILES Oc1ncc(cc1N)c1ccncc1
InChI InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
InChI Key RNLQIBCLLYYYFJ-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1984))
IUPAC Name Click here for help
3-amino-5-(pyridin-4-yl)pyridin-2-ol
International Nonproprietary Names Click here for help
INN number INN
4310 amrinone
Synonyms Click here for help
amrinone lactate | Inocor® | WIN-40680
Database Links Click here for help
CAS Registry No. 60719-84-8
ChEMBL Ligand CHEMBL12856
DrugBank Ligand DB01427
DrugCentral Ligand 201
GtoPdb PubChem SID 178103777
PubChem CID 3698
Search Google for chemical match using the InChIKey RNLQIBCLLYYYFJ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone RNLQIBCLLYYYFJ
Search PubMed clinical trials amrinone
Search PubMed titles amrinone
Search PubMed titles/abstracts amrinone
UniChem Compound Search for chemical match using the InChIKey RNLQIBCLLYYYFJ-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey RNLQIBCLLYYYFJ-UHFFFAOYSA-N
Wikipedia Amrinone